The Best Humulene Strains for Anti-Inflammation:
Ranked by Price and Potency

Humulene and caryophyllene are the dynamic duo of cannabis's anti-inflammatory terpene toolkit, and they almost always appear together in the same cultivars. Humulene's anti-inflammatory mechanisms include NF-κB inhibition, COX-1/COX-2 suppression, and reduction of pro-inflammatory prostaglandins — overlapping but distinct from caryophyllene's CB2-mediated pathway. This multi-target approach may explain why strains high in both terpenes are so consistently effective for inflammatory conditions. Research has demonstrated humulene's anti-tumor properties in cancer models, which may stem from the same NF-κB suppression underlying its anti-inflammatory activity. In whole-plant THCa products, humulene's relatively low concentration (typically 0.1–0.3%) is offset by its synergistic amplification of caryophyllene and CBD's anti-inflammatory effects. Look for COAs reporting both humulene and caryophyllene for the most complete anti-inflammatory terpene profile.